반응 #488363

반응 방정식

3-bromo-5-ethoxy-4-hydroxybenzaldehyde

copper (I) cyanide

→

Intermediate 51

수율 45.0%

3-ethoxy-5-formyl-2-hydroxybenzonitrile

수율 45.0%

용매

water

DMF

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   추출extracted with EtOAc
3. 3
   건조dried over Na2SO4
4. 4
   농축concentrated under reduced pressure
5. 5
   기타Purified by column chromatography on silica gel

실험 절차

A mixture of 3-bromo-5-ethoxy-4-hydroxybenzaldehyde (200 mg, 0.82 mmol) and copper (I) cyanide in DMF (5 mL) was refluxed overnight. The reaction mixture was diluted with water (20 mL), extracted with EtOAc, dried over Na2SO4, and concentrated under reduced pressure. Purified by column chromatography on silica gel to afford Intermediate 51 (70 mg, yield 45%).

출처