반응 #488353

반응 방정식

3-bromo-5-ethoxy-4-(methoxymethoxy)benzaldehyde

CuCN

EtOAc

→

3-ethoxy-5-formyl-2-hydroxybenzonitrile

수율 50.0%

용매

DMF

반응 조건

후처리

1. 1
   기타was consumed
2. 2
   기타The solvent was removed in vacuo
3. 3
   기타the residue was purified by column chromatography

실험 절차

A mixture of 3-bromo-5-ethoxy-4-(methoxymethoxy)benzaldehyde (600 mg, 2.1 mmol) and CuCN (280 mg, 3.1 mmol) in DMF (10 mL) was heated at 180° C. for 4 hours. TLC (PE:EtOAc=1:1) indicated that the most of the starting material was consumed. The solvent was removed in vacuo, and the residue was purified by column chromatography to afford the 3-ethoxy-5-formyl-2-hydroxybenzonitrile (200 mg, yield: 50.0%).

출처