반응 #48832

반응 방정식

2,4,5-Trifluorophenyl sulfonyl chloride

sodium sulfite

sodium bicarbonate

bromoacetic acid

→

desired compound

수율 66.5%

1,2,4-Trifluoro-5-(methylsulfonyl)benzene

수율 66.5%

용매

water

water

반응 조건

후처리

1. 1
   온도to cool
2. 2
   온도heated to 150° C. for 300 seconds
3. 3
   온도to cool
4. 4
   기타was removed by filtration
5. 5
   기타dried in vacuo

실험 절차

2,4,5-Trifluorophenyl sulfonyl chloride (279 mg) was added to a solution of sodium sulfite (306 mg) and sodium bicarbonate (153 mg) in water (4 mL). The mixture was heated to 150° C. in a sealed microwave vial for 400 seconds and allowed to cool. The mixture was treated with bromoacetic acid (253 mg) in water (1 mL), and heated to 150° C. for 300 seconds then allowed to cool, following which the precipitate was removed by filtration and dried in vacuo to give the desired compound (169 mg). The material was used without further purification. 1H NMR δ (d6-DMSO): 3.35 (s, 3H), 7.87-8.01 (m, 2H).

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