반응 #48823

반응 방정식

3-chloro-4-fluorobenzenesulfonyl chloride

dimethylamine

THF

hydrochloric acid

DIPEA

→

title compound

수율 94.0%

3-Chloro-4-fluoro-N,N-dimethylbenzenesulfonamide

수율 94.0%

용매

DCM

DCM

Water

반응 조건

후처리

1. 1
   온도to warm to rt
2. 2
   기타The organic phase was separated
3. 3
   기타evaporated under reduced pressure

실험 절차

A solution of 2M dimethylamine in THF (5.9 mL, 12 mmol) was diluted with DCM (25 mL) and cooled to 0° C. DIPEA (2.8 mL) was added, followed by and 3-chloro-4-fluorobenzenesulfonyl chloride (2.5 g, 11 mmol) in DCM (25 mL). The resulting mixture was allowed to warm to rt and stirred for 3 hours. Water (5 mL) and 1M hydrochloric acid (16 mL) was added. The organic phase was separated and evaporated under reduced pressure to afford the title compound (2.4 g, 94%).

출처