반응 #488174

반응 방정식

sodium hydroxide

compound

tert-butyl (3S)-4-amino-3-[(tert-butoxycarbonyl)amino]-4-oxobutanoate

dimethylformamide

cyanuric chloride

→

title compound

(S)-tert-butyl 3-(tert-butoxycarbonylamino)-3-cyanopropanoate

용매

toluene

반응 조건

후처리

1. 1
   기타to separate the layers
2. 2
   기타The organic layer thus obtained
3. 3
   세척was washed once again with water (700 ml)
4. 4
   workup.DISTILLATIONdistilled under reduced pressure

실험 절차

To the compound obtained from Example 11 was added dimethylformamide (1019.5 g) followed by addition of cyanuric chloride (112.0 g) dropwise for 1.5 hours at temperature below 25° C. The reaction solution was stirred for one hour at room temperature, and then 0.1 N aqueous sodium hydroxide solution (1850.0 g) and toluene (1860 ml) were added thereto to separate the layers. The organic layer thus obtained was washed once again with water (700 ml) and then distilled under reduced pressure to obtain 318.3 g of the title compound.

출처