반응 #487775

반응 방정식

4-hydroxy-3-methylbenzonitrile

nitronium tetrafluoroborate

→

4-hydroxy-3-methyl-5-nitrobenzonitrile

수율 94.0%

용매

water

acetonitrile

반응 조건

후처리

1. 1
   여과The resulting light yellow precipitate was filtered
2. 2
   세척washed with water
3. 3
   기타dried

실험 절차

A stirred solution of 4-hydroxy-3-methylbenzonitrile (3.1 g, 23.3 mmol) in 60 mL of anhydrous acetonitrile was cooled to −30° C. and treated with nitronium tetrafluoroborate (3.4 g, 25.6 mmol) in portions. After 60 minutes, the reaction mixture was diluted with 100 mL of water. The resulting light yellow precipitate was filtered, washed with water, and dried to give 3.9 g of 4-hydroxy-3-methyl-5-nitrobenzonitrile (94% yield).

출처