반응 #487774

반응 방정식

4-cyano-2-methylphenyl acetate

potassium carbonate

→

4-hydroxy-3-methylbenzonitrile

수율 78.4%

용매

methanol

water

반응 조건

후처리

1. 1
   농축the mixture was concentrated in vacuo
2. 2
   workup.ADDITIONtreated with 1 N sulfuric acid
3. 3
   여과The resulting precipitate was filtered
4. 4
   세척washed with water
5. 5
   기타dried

실험 절차

A stirred solution of 4-cyano-2-methylphenyl acetate (5.2 g, 29.7 mmol) in 75 mL of methanol was treated with a solution of potassium carbonate (30 mmol, 4.15 g) in 25 mL of water at room temperature. After 30 minutes, the mixture was concentrated in vacuo and treated with 1 N sulfuric acid. The resulting precipitate was filtered, washed with water, and dried to give 3.1 g of 4-hydroxy-3-methylbenzonitrile as a white solid (78% yield).

출처