반응 #487667

반응 방정식

hydrazine acetate

2,4-Dioxo-4-phenyl-butyric acid methyl ester

water

→

desired product

수율 66.3%

5-phenyl-1H-pyrazole-3-carboxylic acid methyl ester

수율 66.3%

용매

acetic acid

반응 조건

후처리

1. 1
   여과The precipitate was filtered
2. 2
   workup.STIRRINGstirred with diisopropylether
3. 3
   여과again filtered

실험 절차

983 mg hydrazine acetate was added to 2 g 2,4-Dioxo-4-phenyl-butyric acid methyl ester in 10 mL concentrated acetic acid. The mixture was stirred over night at RT. Then water was added. The precipitate was filtered, stirred with diisopropylether and again filtered to give 1.3 g desired product. Rt: 1.39 min (method O), (M+H)+: 203

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