반응 #487573

반응 방정식

phosphoryl chloride

DMF

barbituric acid

→

2,4,6-trioxohexahydropyrimidine-5-carbaldehyde

반응 조건

후처리

1. 1
   온도cooling
2. 2
   온도The mixture is cooled
3. 3
   기타the precipitate is separated off
4. 4
   세척rinsed with water
5. 5
   기타dried at 45°
6. 6
   기타giving 2.5 g of “1”

실험 절차

9.03 ml of phosphoryl chloride are added dropwise to 2 ml of dry DMF with ice-cooling. 1.5 g of barbituric acid are subsequently added, and the mixture is stirred at 100° for 4 h. The mixture is cooled, poured into ice-water, the precipitate is separated off, rinsed with water and dried at 45°, giving 2.5 g of “1”.

출처