반응 #487565

반응 방정식

NaOH

1H-pyrrolo[2,3-b]pyridine 7-oxide

N,N-dimethylformamide

methanesulfonyl chloride

→

wet pale orange solid

수율 135.4%

4-Chloro-1H-pyrrolo[2,3-b]pyridine

수율 135.4%

용매

water

반응 조건

후처리

1. 1
   온도cooled to 40° C
2. 2
   온도the resulting suspension was cooled to 0° C
3. 3
   여과The mixture was filtered
4. 4
   세척washed with water (×3)

실험 절차

To a 50° C. pink solution of 1H-pyrrolo[2,3-b]pyridine 7-oxide (2.47 g, 0.0184 mol) in N,N-dimethylformamide (13.3 mL, 0.172 mol) was added methanesulfonyl chloride (4.0 mL, 0.052 mol). The pink color changed to orange. The mixture was heated to 73° C. for 2 h, and cooled to 40° C. Then 35 mL of water was added and the resulting suspension was cooled to 0° C. NaOH was added to adjust the pH of the mixture to ˜7. The mixture was filtered and washed with water (×3) to give 3.8 g of wet pale orange solid that was dried at 40° C. overnight to give 2.35 g (82.2% yield).

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