반응 #48730
ord-37767759e28946f6af4b9007458d87cf
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반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도Warm
- 2기타reaction mixture to 12° C. over 3.5 hours
- 3세척wash with 5% aqueous citric acid (3×20 mL)
- 4건조Dry over magnesium sulfate
- 5농축concentrate under reduced pressure
실험 절차
Cool a solution of (+/−)-trans-2-hydroxymethyl-cyclopropanecarboxylic acid ethyl ester (0.22 g, 1.53 mmol) in 1.5 mL DMSO to 0° C. Add to the frozen solution triethyl-amine (0.85 mL, 0.62 mmol) followed by sulfur trioxide pyridine (0.49 g, 3.05 mmol). Warm reaction mixture to 12° C. over 3.5 hours, dilute with diethyl ether (80 mL), and wash with 5% aqueous citric acid (3×20 mL) followed by saturated aqueous sodium chloride (1×20 mL). Dry over magnesium sulfate and concentrate under reduced pressure to provide the desired compound.