반응 #48728

반응 방정식

sodium hydroxide

(+/−)-trans-cyclopropane-1,2-dicarboxylic acid diethyl ester

water

→

desired compound

수율 88.7%

(+/−)-trans-cyclopropane-1,2-dicarboxylic acid monoethyl ester

수율 88.7%

용매

ethanol

acetone

반응 조건

후처리

1. 1
   workup.ADDITIONPour
2. 2
   추출extract with ethyl acetate (1×70 mL)
3. 3
   농축concentrate under reduced pressure
4. 4
   여과Add ethyl acetate and filter the resulting slurry
5. 5
   농축Concentrate the filtrate under reduced pressure

실험 절차

Add a solution of 0.709 g (17.72 mmol) sodium hydroxide in 7.38 mL ethanol to a solution of (+/−)-trans-cyclopropane-1,2-dicarboxylic acid diethyl ester (3.00 g, 16.11 mmol) in 36.9 mL acetone. Stir at room temperature for 24 hours. Pour reaction mixture into 100 mL water and extract with ethyl acetate (1×70 mL). Acidify the aqueous layer with 5N HCl and concentrate under reduced pressure. Add ethyl acetate and filter the resulting slurry. Concentrate the filtrate under reduced pressure to provide the desired compound (2.26 g, 88.7%).

출처