반응 #4872

반응 방정식

ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate

sodium hydroxide

→

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

수율 75.1%

용매

methanol

반응 조건

후처리

1. 1
   온도the mixture is refluxed for 30 minutes
2. 2
   온도under heating
3. 3
   온도After cooling
4. 4
   기타crystalline precipitates
5. 5
   여과are collected by filtration
6. 6
   세척washed with methanol
7. 7
   기타Crystalline precipitates
8. 8
   여과are collected by filtration
9. 9
   기타dried

실험 절차

16.0 g of ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are added to a mixture of 160 ml of methanol and 30 ml of an aqueous 2N sodium hydroxide solution, and the mixture is refluxed for 30 minutes under heating. After cooling, crystalline precipitates are collected by filtration and washed with methanol. The crystals are suspended in 30 ml of water. Then, the suspension is adjusted to pH 3 with 2N hydrochloric acid. Crystalline precipitates are collected by filtration and dried. 11.4 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained.

출처