반응 #48713

반응 방정식

propyl iodide

3-bromo-5-fluoro-phenol

cesium carbonate

→

desired compound

1-bromo-3-fluoro-5-propoxy-benzene

용매

N,N-dimethylformamide

—

hexanes

반응 조건

후처리

1. 1
   온도heat at 50° C. for 1 hour
2. 2
   온도Cool to room temperature
3. 3
   세척Wash (water, 1N lithium chloride, saturated aqueous sodium chloride)
4. 4
   건조dry (magnesium sulfate)
5. 5
   여과filter
6. 6
   농축concentrate

실험 절차

Add propyl iodide (5.74 g, 33.77 mmol) to 3-bromo-5-fluoro-phenol (4.30 g, 22.51 mmol) and cesium carbonate (11.00 g, 33.77 mmol) in N,N-dimethylformamide (75 mL) and stir at room temperature 1 hour, then heat at 50° C. for 1 hour. Cool to room temperature and dilute with hexanes. Wash (water, 1N lithium chloride, saturated aqueous sodium chloride), dry (magnesium sulfate), filter and concentrate to give the desired compound as a colorless oil, 4.40 g (83.8%).

출처