반응 #48680

반응 방정식

(2R,3S,5S)-5-benzyloxymethyl-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester

→

desired compound

수율 93.3%

(2R,3S,5S)-2-(2,2-Dimethylpropoxy)-5-hydroxymethyl-3-methylmorpholine-4-carboxylic acid tert-butyl ester

수율 93.3%

용매

methanol

반응 조건

후처리

1. 1
   여과Filter through Celite®
2. 2
   농축concentrate
3. 3
   기타purify
4. 4
   세척(silica gel chromatography, eluting with 0:100 to 20:80 ethyl acetate:hexanes)

실험 절차

Stir (2R,3S,5S)-5-benzyloxymethyl-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester (0.65 g, 1.59 mmol) and 20% palladium hydroxide on carbon (0.65 g) in methanol (25 mL) under a hydrogen atmosphere at room temperature for 2 hours. Filter through Celite®, concentrate and purify (silica gel chromatography, eluting with 0:100 to 20:80 ethyl acetate:hexanes) to give the desired compound as an oil (471 mg 93.0%).

출처