반응 #48658

반응 방정식

(R)-2-phenoxymethyl-oxirane

hydrogen

→

desired compound

수율 58.0%

(R)-2-Cyclohexyloxymethyl-oxirane

수율 58.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타In two separate runs
2. 2
   여과Filter through a filtering agent
3. 3
   세척wash with tetrahydrofuran
4. 4
   농축concentrate
5. 5
   기타purify
6. 6
   세척(silica gel chromatography, eluting with 5:95 to 30:70 ethyl acetate:hexanes)

실험 절차

In two separate runs, dissolve (R)-2-phenoxymethyl-oxirane (1.410 g, 9.389 mmol) in tetrahydrofuran (50 mL). Add 5% ruthenium on carbon (0.71 g) and hydrogenate at 60 psi of hydrogen gas for 40 minutes. Filter through a filtering agent, wash with tetrahydrofuran, concentrate and purify (silica gel chromatography, eluting with 5:95 to 30:70 ethyl acetate:hexanes) to give the desired compound as a clear liquid (0.850 g, 57.9% combined yield).

출처