반응 #48645

반응 방정식

(R)-(+)-2-amino-3-benzyloxy-1-propanol

2-(S)-(2-cyclohexylethyl)-oxirane

→

desired compound

수율 57.2%

1-(1-(R)-benzyloxymethyl-2-hydroxyethylamino)-4-cyclohexylbutan-2-(S)-ol

수율 57.2%

용매

ethanol

반응 조건

후처리

1. 1
   농축Concentrate
2. 2
   기타purify
3. 3
   세척(silica gel chromatography, eluting with 8:92 to 10:90 methanol:dichloromethane)

실험 절차

Dissolve (R)-(+)-2-amino-3-benzyloxy-1-propanol (317 mg, 1.75 mmol) and 2-(S)-(2-cyclohexylethyl)-oxirane (270 mg, 1.75 mmol) in absolute ethanol (8 mL) and heat at 80° C. in a sealed glass pressure vessel overnight. Concentrate and purify (silica gel chromatography, eluting with 8:92 to 10:90 methanol:dichloromethane) to give the desired compound (336 mg, 57%).

출처