반응 #48644

반응 방정식

triethylamine

acetic anhydride

5-(R)-[2-(S)-amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(S)-(2-cyclohexylethyl)-morpholine-4-carboxylic acid tert-butyl ester

→

title compound

수율 37.5%

5-(R)-[2-(S)-Acetylamino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(S)-(2-cyclohexylethyl)-morpholine-4-carboxylic acid tert-butyl ester

수율 37.5%

용매

tetrahydrofuran

dichloromethane

반응 조건

후처리

1. 1
   세척wash with 0.1 N hydrochloric acid (30 mL)
2. 2
   건조dry (sodium sulfate)
3. 3
   여과filter
4. 4
   농축concentrate
5. 5
   기타purify
6. 6
   세척(silica gel chromatography, eluting with 45:55 to 70:30 ethyl acetate:dichloromethane)

실험 절차

Add triethylamine (0.04 mL, 0.32 mmol) followed by acetic anhydride (0.03 mL, 0.32 mmol) to a solution of 5-(R)-[2-(S)-amino-3-(3,5-difluorophenyl)-1-(S)-hydroxypropyl]-2-(S)-(2-cyclohexylethyl)-morpholine-4-carboxylic acid tert-butyl ester (138 mg, 0.29 mmol) in dry tetrahydrofuran (3 mL). Stir at room temperature for 10 min. Dilute with dichloromethane, wash with 0.1 N hydrochloric acid (30 mL), dry (sodium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 45:55 to 70:30 ethyl acetate:dichloromethane) to give the title compound (57 mg).

출처