반응 #486252

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solution

4,4-Dichloro-3-(4-methylthiophenyl)-2-phenyl-2-cyclobuten-1-one

THF

→

title compound

4,4-Dichloro-3-methylene-1-(4-methylthiophenyl)-2-phenyl-1-cyclobutene

반응 조건

후처리

1. 1
   기타quenched with NaOH 0.5N at 0° C.
2. 2
   workup.ADDITIONdiluted with Et2O
3. 3
   세척The organic phase was washed with H2O, brine
4. 4
   건조dried (MgSO4)
5. 5
   기타the solvents evaporated

실험 절차

To a solution of Example 1 (810 mg) in THF (20 mL) at 0° C. was added Tebbe's reagent (0.5M, 5 mL) dropwise. The mixture was stirred at r.t. for 30 min., quenched with NaOH 0.5N at 0° C. and diluted with Et2O. The organic phase was washed with H2O, brine, dried (MgSO4) and the solvents evaporated. Flash chromatography of the residue (silica gel; hexane/EtOAc (95:5)) provided the title compound as a yellow oil.

출처