반응 #48622

반응 방정식

3-hydroxybenzaldehyde

nitromethane

tetrabutylammonium fluoride

→

desired compound

수율 90.0%

3-(1-Hydroxy-2-nitroethyl)-phenol

수율 90.0%

용매

tetrahydrofuran

ethyl acetate

반응 조건

후처리

1. 1
   세척wash with water (3×500 mL) and saturated aqueous sodium chloride (200 mL)
2. 2
   추출Extract the aqueous washes with diethyl ether (3×)
3. 3
   세척wash with saturated aqueous sodium chloride
4. 4
   건조dry (magnesium sulfate)
5. 5
   여과filter through a pad of silica gel
6. 6
   농축concentrate
7. 7
   온도cool
8. 8
   여과filter solid
9. 9
   세척eluting with 5:95 ethyl acetate

실험 절차

Dissolve 3-hydroxybenzaldehyde (18.4 g, 15.07 mmol) in tetrahydrofuran (100 mL). Add nitromethane ((42 mL, 780 mmol), cool in an ice bath and add tetrabutylammonium fluoride (151 mL, 151 mmol, 1.0 M in tetrahydrofuran). Stir for 2 hours, dilute with ethyl acetate (200 mL), wash with water (3×500 mL) and saturated aqueous sodium chloride (200 mL). Extract the aqueous washes with diethyl ether (3×), wash with saturated aqueous sodium chloride, dry (magnesium sulfate), filter through a pad of silica gel, and concentrate. Suspend the residue in hot dichloromethane with 5% ethyl acetate, cool and filter solid. Purify filtrate using silica gel chromatography, eluting with 5:95 ethyl acetate:dichloromethane. Combine the solid from the dichloromethane tritutation with the purified filtrate to give the desired compound (24.88 g, 90% total yield).

출처