반응 #486184

반응 방정식

potassium carbonate

2-chlorothiophenol

methyl 3-bromomethylthien-2-ylglyoxylate

→

abovementioned compound

수율 68.3%

Methyl 3-(2-chlorothiophenoxymethyl)-thien-2-yl-glyoxylate

수율 68.3%

용매

acetone

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타the filtrate is evaporated down
3. 3
   세척the solution is washed with Na2CO3 solution
4. 4
   기타dried
5. 5
   기타evaporated down
6. 6
   기타The crude product is recrystallized from methanol

실험 절차

2.62 g (19 mmol) of potassium carbonate and 2.74 g (19 mmol) of 2-chlorothiophenol are added to a solution of 5 g (19 mmol) of methyl 3-bromomethylthien-2-ylglyoxylate in 50 ml of acetone, the mixture is stirred for 72 hours at room temperature and filtered and the filtrate is evaporated down. The residue is taken up in methylene chloride, and the solution is washed with Na2CO3 solution, dried and evaporated down. The crude product is recrystallized from methanol. 4.24 g (68%) of the abovementioned compound are obtained.

출처