반응 #48611

반응 방정식

(R)-4-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

sodium borohydride

water

→

desired compound

수율 95.0%

(R)-4-[(1S,2S)-2-Amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

수율 95.0%

용매

methanol

반응 조건

후처리

1. 1
   농축Concentrate
2. 2
   workup.DISSOLUTIONdissolve the residue in ethyl acetate
3. 3
   여과Filter the black solution through a pad of Celite®
4. 4
   세척wash the filter cake with ethyl acetate
5. 5
   세척Wash the filtrate with water (twice), saturated aqueous sodium chloride
6. 6
   건조dry (magnesium sulfate)
7. 7
   여과filter
8. 8
   농축concentrate

실험 절차

Combine (R)-4-[(1R,2S)-3-(3,5-difluorophenyl)-1-hydroxy-2-nitropropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (1.13 g, 2.71 mmol) and nickel (II) chloride (0.58 g, 4.485 mmol) in dry methanol (30 ml) and add sodium borohydride (0.454 g, 12 mmol) over 1 minute. Stir the resulting mixture for 20 minutes and then add water (3 mL). Concentrate and dissolve the residue in ethyl acetate. Filter the black solution through a pad of Celite® and wash the filter cake with ethyl acetate. Wash the filtrate with water (twice), saturated aqueous sodium chloride, dry (magnesium sulfate), filter, and concentrate to give the desired compound as a white solid (920 mg, 95%).

출처