반응 #48594

반응 방정식

benzaldehyde

malononitrile

ethanol

→

2-benzylidene-but-3-yne nitrile

반응 조건

후처리

1. 1
   온도the mixture was heated
2. 2
   온도at reflux overnight
3. 3
   온도The reaction was cooled
4. 4
   기타evaporated
5. 5
   기타then purified by flash column chromatography
6. 6
   세척eluting with 1:9 ethyl acetate/hexane
7. 7
   workup.ADDITIONthe product containing fractions
8. 8
   기타evaporated

실험 절차

To a solution of benzaldehyde (2 g; 18.9 mmol) and malononitrile (1.37 g; 20.7 mmol) in ethanol (40 ml) was added 5 drops of piperidine and the mixture was heated at reflux overnight. The reaction was cooled, evaporated then purified by flash column chromatography eluting with 1:9 ethyl acetate/hexane and the product containing fractions combined and evaporated to give 930 mg of 2-benzylidene-but-3-yne nitrile.

출처