반응 #48568

반응 방정식

4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

2,3-dichloropyrazine

→

title compound

수율 19.6%

4-(3-Chloro-pyrazin-2-ylamino)-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

수율 19.6%

반응 조건

후처리

1. 1
   기타The crude reaction mixture
2. 2
   기타was purified by flash column chromatography
3. 3
   세척eluting with ethyl acetate/hexane (1:3
4. 4
   workup.ADDITIONProduct containing fractions
5. 5
   기타evaporated

실험 절차

A mixture of 4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide (50 mg; 0.23 mmol) and 2,3-dichloropyrazine (140 mg; 0.92 mmol) was heated at 150° C. (50W) for 20 minutes in a CEM Discover™ microwave synthesiser. The crude reaction mixture was purified by flash column chromatography eluting with ethyl acetate/hexane (1:3 then 1:2). Product containing fractions were combined and evaporated to give 15 mg of the title compound as a white solid. (LC/MS: Rt 4.06 M+H]+ 332).

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