반응 #48567

반응 방정식

4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

cyclohexanone

sodium triacetoxyborohydride

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product

수율 15.9%

4-Cyclohexylamino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide

수율 15.9%

용매

dichloromethane

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered through Celite®
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   세척washed with brine
4. 4
   건조dried (MgSO4)
5. 5
   기타evaporated

실험 절차

To a solution of 4-amino-1H-pyrazole-3-carboxylic acid (4-fluoro-phenyl)-amide (200 mg; 1 mmol) and cyclohexanone (107 mg; 1.1 mmol) in dichloromethane (10 ml) were added 3 Å molecular sieves (1 g) and sodium triacetoxyborohydride (315 mg; 1.5 mmol), and the mixture was then stirred at room temperature over the weekend. The reaction mixture was filtered through Celite®, diluted with ethyl acetate, washed with brine, dried (MgSO4) and evaporated to give the 48 mg of the product as a grey gum. (LC/MS: Rt 2.95, [M+H]+ 285).

출처