반응 #48555

반응 방정식

Triethylamine

4-chlorophenyl isothiocyanate

4-cyano-4-phenylpiperidine hydrochloride

→

title compound

N-(4-Chlorophenyl)-4-cyano-4-phenylpiperidine-1-carbothioamide

용매

dichloromethane

반응 조건

후처리

1. 1
   세척The mixture was washed with 2N hydrochloric acid
2. 2
   건조brine, it was dried over MgSO4
3. 3
   기타evaporated under reduced pressure

실험 절차

Triethylamine (1.4 mL, 10 mmol) was added to a suspension of 4-chlorophenyl isothiocyanate (1.69 g, 10 mmol) and 4-cyano-4-phenylpiperidine hydrochloride (2.22 g, 10 mmol) in dichloromethane (100 mL), and the reaction was then stirred at room temperature for 20 minutes. The mixture was washed with 2N hydrochloric acid, then brine, it was dried over MgSO4 and evaporated under reduced pressure to afford the title compound as a white solid, 3.62 g.

출처