반응 #4854

반응 방정식

2,3-dihydro-5,7-dinitro-2-methylbenzofuran

ammonia

Methyl Cellosolve

→

expected product

1-(2-amino-3,5-dinitrophenyl)-2-propanol

용매

water

반응 조건

후처리

1. 1
   온도the reaction mixture is cooled
2. 2
   기타The precipitate formed
3. 3
   기타then dried under vacuum
4. 4
   기타is recrystallized from 170 ml of dioxane
5. 5
   기타After being dried under vacuum

실험 절차

0.39 Mole (88 g) of 2,3-dihydro-5,7-dinitro-2-methylbenzofuran, prepared according to J.A.C.S. 80, p. 4711-4714 (1958), is suspended in 1.1 l of 20% strength ammonia solution and 600 ml of Methyl Cellosolve. After 18 hours' heating at 70° C., the reaction mixture is cooled. The precipitate formed is drained and, after being made into a paste in water until neutral and then dried under vacuum, is recrystallized from 170 ml of dioxane. After being dried under vacuum, 0.30 mole (72 g) of the expected product is obtained; it melts at 177° C.

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