반응 #48512

반응 방정식

sodium hydroxide

benzyl 4-[3-(tert-butoxycarbonylmethyl)-2-oxotetrahydropyrimidin-1(2H)-yl]piperidin-1-carboxylate

→

title compound

수율 101.4%

[3-{1-[(Benzyloxy)carbonyl]piperidin-4-yl}-2-oxotetrahydropyrimidin-1(2H)-yl]acetic acid

수율 101.4%

용매

ethanol

반응 조건

후처리

1. 1
   workup.DISTILLATIONEthanol was distilled off under reduced pressure, and 1N hydrochloric acid
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   추출followed by extraction with chloroform
4. 4
   건조The extract was dried over anhydrous magnesium sulfate
5. 5
   농축concentrated under reduced pressure

실험 절차

An aqueous 4N sodium hydroxide solution (10 mL) was added to a solution of benzyl 4-[3-(tert-butoxycarbonylmethyl)-2-oxotetrahydropyrimidin-1(2H)-yl]piperidin-1-carboxylate (1.7 g) obtained in Example 35a) in ethanol (20 mL), and the mixture was stirred at room temperature overnight. Ethanol was distilled off under reduced pressure, and 1N hydrochloric acid was added to the residue to adjust pH to 3, followed by extraction with chloroform. The extract was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain the title compound (1.5 g, quantitative) as a white powder.

출처