반응 #48405

반응 방정식

water

Triethylamine

2,4-dimethoxybenzylamine hydrochloride

2,3-dibromopropene

→

title compound

수율 50.3%

2-Bromo-N-(2,4-dimethoxybenzyl)prop-2-en-1-amine

수율 50.3%

용매

dichloromethane

반응 조건

후처리

1. 1
   추출the mixture was extracted with dichloromethane (3×)
2. 2
   세척The combined organic extracts were washed with saturated brine
3. 3
   건조dried over magnesium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated
6. 6
   기타Purification by silica gel chromatography [100% dichloromethane→95% dichloromethane/5% (10% ammonium hydroxide/methanol)]

실험 절차

Triethylamine (16.0 mL, 114 mmol) was added to a solution of 2,4-dimethoxybenzylamine hydrochloride (11.1 g, 54.5 mmol) and 2,3-dibromopropene (10.9 g, 54.5 mmol) in dichloromethane (200 mL). After 18 h, water was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts were washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. Purification by silica gel chromatography [100% dichloromethane→95% dichloromethane/5% (10% ammonium hydroxide/methanol)] gave the title compound (7.85 g).

출처