반응 #48344

ord-de5afd8195a94c1e80d9d1d910874574

반응 방정식

CC(C)(C)[S@](=O)/N=C/[C@@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
(S,E)-N-((S)-2,3-bis(tert-butyldimethylsilyloxy)propylidene)-2-methylpropane-2-sulfinamide
Fc1ccc(CBr)cc1Br
2-bromo-4-(bromomethyl)-1-fluorobenzene
→
CC(C)(C)[S@](=O)N[C@@H](Cc1ccc(F)c(Br)c1)[C@@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
title compound
CC(C)(C)[S@](=O)N[C@@H](Cc1ccc(F)c(Br)c1)[C@@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
(S)—N-((2S,3S)-1-(3-Bromo-4-fluorophenyl)-3,4-bis(tert-butyldimethylsilyloxy)butan-2-yl)-2-methylpropane-2-sulfinamide

반응물

CC(C)(C)[S@](=O)/N=C/[C@@H](CO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
(S,E)-N-((S)-2,3-bis(tert-butyldimethylsilyloxy)propylidene)-2-methylpropane-2-sulfinamide
Fc1ccc(CBr)cc1Br
2-bromo-4-(bromomethyl)-1-fluorobenzene

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared from (S,E)-N-((S)-2,3-bis(tert-butyldimethylsilyloxy)propylidene)-2-methylpropane-2-sulfinamide and 2-bromo-4-(bromomethyl)-1-fluorobenzene using a method analogous to that described in Examples 509 and 510.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07745484B2uspto-grants-2010_06