반응 #48279

반응 방정식

4-(2,2-dimethoxyethyl)hepta-1,6-dien-4-ol

tetrakis-(hydroxymethyl)phosphonium chloride

→

title compound

2,2-dimethoxyethylcyclopent-3-enol

용매

DCM

water

isopropanol

NaOH

반응 조건

후처리

1. 1
   기타Dry argon was bubbled through the solution for 30 minutes
2. 2
   workup.STIRRINGstirred for 15 hours
3. 3
   workup.ADDITIONpoured into a seperatory funnel
4. 4
   기타The DCM layer was separated
5. 5
   추출the aqueous was extracted with DCM (3×100 mL)
6. 6
   농축The combined organics were concentrated to a dark oil which
7. 7
   기타was purified by flash chromatography on a 330 g ISCO column
8. 8
   세척eluting by gradient hexanes to 20% EtOAc/ hexanes over a 50 minute period

실험 절차

A solution of 4-(2,2-dimethoxyethyl)hepta-1,6-dien-4-ol (28 g, 140 mmol) in DCM (2L) was charged to a 3 L RB flask. Dry argon was bubbled through the solution for 30 minutes. Grubbs second generation catalyst (5.9 g, 7.0 mmol) was added and the reaction was allowed to stir under argon for 15 hours. The reaction was quenched with a solution of tetrakis-(hydroxymethyl)phosphonium chloride (27 g, 140 mmol) in isopropanol (200 mL) and 10 N NaOH (14 mL), and stirred for 15 hours. The reaction was diluted with water (1 L) and poured into a seperatory funnel. The DCM layer was separated and the aqueous was extracted with DCM (3×100 mL). The combined organics were concentrated to a dark oil which was purified by flash chromatography on a 330 g ISCO column eluting by gradient hexanes to 20% EtOAc/ hexanes over a 50 minute period. Product fractions were combined to afford the title compound.

출처