반응 #48265

반응 방정식

Potassium carbonate

2-methoxy-5-nitro phenol

benzyl bromide

→

1-Benzyloxy-2-methoxy-5-nitrobenzene

수율 96.5%

용매

acetone

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 12 hours
2. 2
   기타The solvent was removed under reduced pressure
3. 3
   기타the residue was partitioned between ethyl acetate (150 ml) and water (50 ml)
4. 4
   기타The ethyl acetate layer was separated
5. 5
   세척washed with water (2×50 ml)
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   기타Removal of the solvent under reduced pressure

실험 절차

Potassium carbonate (1.65 gm; 12 mmol) was added to a solution of 2-methoxy-5-nitro phenol (1.69 g; 10 mmol) and benzyl bromide (1.71 gm; 10 mmol) in acetone (60 ml). The reaction mixture was refluxed for 12 hours. The solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate (150 ml) and water (50 ml). The ethyl acetate layer was separated, washed with water (2×50 ml), dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.5 g of 1-Benzyloxy-2-methoxy-5-nitrobenzene (Yield=96.5%)

출처