반응 #48263

반응 방정식

Potassium carbonate

3,4-dihydroxybenzoic acid methyl ester

benzyl bromide

→

3,4-Dibenzyloxy benzoic acid methyl ester

수율 122.9%

용매

acetone

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 12 hrs
2. 2
   기타After the removal of the solvent under reduced pressure
3. 3
   기타the residue was partitioned between ethyl acetate (150 ml) and water (50 ml)
4. 4
   세척The ethyl acetate layer was washed with water (50 ml)
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   기타Removal of the solvent under reduced pressure

실험 절차

Potassium carbonate (6.5 g; 47 mmol) was added to a solution of 3,4-dihydroxybenzoic acid methyl ester (2.6 g; 15.7 mmol) and benzyl bromide (5.37 g; 31.4 mmol) in acetone (100 ml). The reaction mixture was refluxed for 12 hrs. After the removal of the solvent under reduced pressure, the residue was partitioned between ethyl acetate (150 ml) and water (50 ml). The ethyl acetate layer was washed with water (50 ml) and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 3.36 g of 3,4-Dibenzyloxy benzoic acid methyl ester (Yield=86.6%)

출처