반응 #482031

반응 방정식

4-chlorobenzonitrile

potassium carbonate

1-butanethiol

water

→

4-n-butylthio-benzonitrile

용매

DMA

DMA

반응 조건

후처리

1. 1
   workup.ADDITIONare added under an atmosphere of nitrogen
2. 2
   온도Then, the reaction mixture is cooled to room temperature
3. 3
   추출The crude product is extracted with 300 ml of ethyl acetate
4. 4
   세척washed with water
5. 5
   건조dried over MgSO4
6. 6
   기타Thereafter, ethyl acetate is removed
7. 7
   workup.DISTILLATIONThen, fractional distillation

실험 절차

To a well-stirred suspension of 41.27 g (0.3 mol) of 4-chlorobenzonitrile, 58.05 g (0.42 mol) of potassium carbonate and 200 ml DMA a solution of 27.06 g (0.3 mol) of 1-butanethiol in 50 ml of DMA are added under an atmosphere of nitrogen. The resulting mixture is heated to 80° C. and stirred at this temperature for 24 hours. Then, the reaction mixture is cooled to room temperature and poured into 750 ml of water. The crude product is extracted with 300 ml of ethyl acetate, washed with water, dried over MgSO4. Thereafter, ethyl acetate is removed. Then, fractional distillation yields 52.88 9 (80.4%) of colorless liquid 4-n-butylthio-benzonitrile.

출처