반응 #48196

반응 방정식

Phosphorous tribromide

(4-benzyloxy-3-chlorophenyl)-methanol

→

1-Benzyloxy-4-bromomethyl-2-chloro-benzene

용매

diethyl ether

dichloromethane

반응 조건

후처리

1. 1
   기타transferred into a separation funnel
2. 2
   세척washed with water (50 mL) and brine (50 mL)
3. 3
   건조The organic layer was dried over magnesium sulphate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타to give a white, analytical pure solid

실험 절차

Phosphorous tribromide (2 mL) was added to a solution of (4-benzyloxy-3-chlorophenyl)-methanol (CAB02127, 3.40 g, 13.7 mmol) in dichloromethane (50 mL) at 0° C. The mixture was stirred at this temperature for 1 h, diluted with diethyl ether (100 mL), transferred into a separation funnel and washed with water (50 mL) and brine (50 mL). The organic layer was dried over magnesium sulphate and concentrated under reduced pressure to give a white, analytical pure solid. Yield: 4.27 g (100%).

출처