반응 #481926

반응 방정식

6-amino-4-[(3-bromophenyl)amino]quinazoline

trans-crotonyl chloride

→

title compound

수율 52.0%

N-[4-[(3-Bromophenyl)amino]quinazolin-6-yl]-E-but-2-enamide

수율 52.0%

용매

THF

반응 조건

후처리

1. 1
   기타A yellow solid formed upon addition
2. 2
   여과The solid was collected by Buchner filtration after 2.5 hours
3. 3
   기타sonicated with EtOAc

실험 절차

To a solution of 6-amino-4-[(3-bromophenyl)amino]quinazoline (316 mg, 1.0 mmol) in THF (6 mL) stirred under N2 at 0° C. was added trans-crotonyl chloride. A yellow solid formed upon addition. The solid was collected by Buchner filtration after 2.5 hours and sonicated with EtOAc to give the title compound (216 mg, 52%), mp 279-281° C.

출처