반응 #481600

반응 방정식

3,4,5-trimethoxy benzaldehyde

sulphuric acid

→

3,5-Dimethoxy-4-hydroxy benzaldehyde

반응 조건

후처리

1. 1
   기타at 40° C.
2. 2
   기타for 8 hours

실험 절차

Monodemethylation of 3,4,5-trimethoxy benzaldehyde using sulphuric acid at 40° C. for 8 hours yields 3,5-Dimethoxy-4-hydroxy benzaldehyde (Syringaldehyde). Condensation of syringaldehyde with ethyl cyanoacetate in the presence of piperidine—acetic acid and benzene as the reaction medium at reflux temperature under continuous azeotropic water removal yields the title product. The reaction takes about 1.5 hours for completion. The yield obtained is typically 95%.

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