반응 #4816

반응 방정식

chloromethyl n-dodecanoate

quinuclidine

KBr

→

n-Dodecanoyloxymethylquinuclidinium Chloride

용매

ether

반응 조건

후처리

1. 1
   기타to react together at room temperature for 48 hrs
2. 2
   기타the mixture was triturated in anydrous ether overnite
3. 3
   기타The solid was isolated by filtration under a nitrogen atmosphere
4. 4
   세척thoroughly washed with anhydrous ether
5. 5
   건조After drying in vacuo over calcium sulfate at room temperature
6. 6
   기타2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

실험 절차

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

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