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(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

intermediate 1

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone

2-morpholino-5-pyridine boronic acid

→

title compound

(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(6-morpholin-4-yl-pyridin-3-yl)-1H-indol-2-yl]-methanone

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후처리

1. 1
   기타In analogy to the procedure described for the synthesis of example 6

실험 절차

In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 2-morpholino-5-pyridine boronic acid. The title compound was obtained in 7% yield as yellow solid. MS (m/e): 568.4 (MH+, 100%).

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