반응 #481456

반응 방정식

thiobenzamide

1,3-dichloroacetone

sodium iodide

4-chloromethyl-2-phenyl-thiazole

→

4-iodomethyl-2-phenyl-thiazole

수율 99.5%

용매

acetone

water

tert-butyl methyl ether

반응 조건

후처리

1. 1
   온도at reflux for 2 hours
2. 2
   기타the mixture was transferred to a separatory funnel
3. 3
   세척The organic phase was washed with water and brine
4. 4
   건조dried with anhydrous sodium sulfate
5. 5
   기타finally evaporated

실험 절차

2 g (13.35 mmol) of sodium iodide were added to a solution of 0.56 g (2.67 mmol) of 4-chloromethyl-2-phenyl-thiazole (prepared from thiobenzamide and 1,3-dichloroacetone in analogy to the procedure described in example 4 a]) in 10 ml of acetone and the suspension was stirred at reflux for 2 hours. After cooling to ambient temperature, 30 ml of tert-butyl methyl ether and 10 ml of water were added and the mixture was transferred to a separatory funnel. The organic phase was washed with water and brine, dried with anhydrous sodium sulfate and finally evaporated, leaving 0.8 g of 4-iodomethyl-2-phenyl-thiazole as light yellow solid (99% of theory).

출처