반응 #48091

ord-e4164ec0b4f04dbcb326a5f2cfbbf628

반응 방정식

CC(C)(C)c1ccc(CN(CCc2cc(F)cc(C(F)(F)F)c2)C(=O)c2cc(Cl)cc(Br)c2)cc1
3-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-benzamide
CCCB(O)O
n-propylboronic acid
→
CCCc1cc(Cl)cc(C(=O)N(CCc2cc(F)cc(C(F)(F)F)c2)Cc2ccc(C(C)(C)C)cc2)c1
N-(4-tert-butyl-benzyl)-3-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-5-propyl-benzamide
CCCc1cc(Cl)cc(C(=O)N(CCc2cc(F)cc(C(F)(F)F)c2)Cc2ccc(C(C)(C)C)cc2)c1
title compound

반응물

CC(C)(C)c1ccc(CN(CCc2cc(F)cc(C(F)(F)F)c2)C(=O)c2cc(Cl)cc(Br)c2)cc1
3-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-benzamide
CCCB(O)O
n-propylboronic acid

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared in analogy to example 3, using 3-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-fluoro-5-trifluoromethyl-phenyl)-ethyl]-benzamide (Example B177) and n-propylboronic acid. 534.3 [ISP (M+H)+]

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07745477B2uspto-grants-2010_06