반응 #480747

반응 방정식

water

2-phenylethanesulfonamide

acetic acid

trioxane

→

title compound

1,2,4,5-tetrahydro-3,2-benzothiazepine-3,3-dioxide

용매

methanesulfonic acid

trifluoroacetic acid

반응 조건

후처리

1. 1
   추출was extracted with chloroform
2. 2
   세척The organic layer was washed with water
3. 3
   건조a saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate
4. 4
   농축was concentrated
5. 5
   기타The residue was purified by column chromatography on silica gel (chloroform:methanol=100:1)

실험 절차

To a solution of 2-phenylethanesulfonamide (3.62 g) in methanesulfonic acid (20 ml)-acetic acid (5 ml) was added a solution of trioxane (582 mg) in trifluoroacetic acid (3 ml)and the mixture was stirred for 3 hours at 35° C. To the reaction mixture was added water and was extracted with chloroform. The organic layer was washed with water and a saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate and was concentrated. The residue was purified by column chromatography on silica gel (chloroform:methanol=100:1) to give the title compound (1.78 g) having the following physical data.

출처