반응 #48052

반응 방정식

4-bromomethyl-1-chloro-2-trifluoromethyl-benzene

sodium cyanide

→

(4-chloro-3-trifluoromethyl-phenyl)-acetonitrile

용매

DMSO

반응 조건

후처리

1. 1
   workup.ADDITIONThe reaction mixture was then poured on water/ice
2. 2
   추출extracted four times with DCM
3. 3
   세척The combined organic phases were washed with water
4. 4
   건조dried with magnesium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo

실험 절차

3.94 g of 4-bromomethyl-1-chloro-2-trifluoromethyl-benzene (14.4 mmol) and 1.06 g sodium cyanide (21.6 mmol) were suspended in 12 ml DMSO under argon and stirring and heated to 50° C. for 1 h. The reaction mixture was then poured on water/ice and extracted four times with DCM. The combined organic phases were washed with water, dried with magnesium sulfate, filtered and concentrated in vacuo, leading to 3.188 g of (4-chloro-3-trifluoromethyl-phenyl)-acetonitrile as a dark red oil, which was directly used in the next step.

출처