반응 #480373

반응 방정식

product

2-Bromo-7-chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidine

4-(2-aminoethyl)benzenesulfonamide

N-ethyldiisopropylamine

→

title compound

수율 78.4%

4-[2-[[7-Chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-yl]amino]ethyl]-benzenesulfonamide

수율 78.4%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The mixture was evaporated to dryness
2. 2
   기타then purified (SiO2, ethyl acetate:dichloromethane 4:6 as eluant)

실험 절차

A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing 4-(2-aminoethyl)benzenesulfonamide (0.161 g) and N-ethyldiisopropylamine (0.5 ml) was stirred for 16 hours. The mixture was evaporated to dryness then purified (SiO2, ethyl acetate:dichloromethane 4:6 as eluant) to give the title compound (310 mg).

출처