반응 #48017

반응 방정식

ethyl ether

sodium hydride

ethyl 5-fluoro-1H-indole-2-carboxylate

sodium hydride

3-bromomethylpyridine hydrobromide

3-bromomethylpyridine hydrobromide

→

expected product

수율 35.4%

Ethyl 5-fluoro-1-[(pyrid-3-yl)methyl]-1H-indole-2-carboxylate

수율 35.4%

용매

dimethylformamide

dimethylformamide

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture is stirred for 30 minutes at 0° C.
2. 2
   온도The reaction mixture is cooled
3. 3
   workup.STIRRINGThe mixture is stirred for 30 minutes at 0° C.
4. 4
   workup.WAITfor 30 minutes at 20° C
5. 5
   온도The reaction mixture is cooled again to 0° C.
6. 6
   workup.WAITAfter 30 minutes at 0° C.
7. 7
   workup.STIRRINGThe reaction mixture is stirred for 58 hours at 20° C
8. 8
   기타The organic phase is separated out
9. 9
   추출the aqueous phase is re-extracted with 100 ml of ethyl ether
10. 10
    세척washed with 50 ml of water
11. 11
    건조dried over sodium sulfate
12. 12
    여과filtered
13. 13
    농축concentrated under reduced pressure
14. 14
    기타The residue is purified by preparative chromatography (eluent: dichloromethane/acetone)

실험 절차

A solution of 1 g (4.73 mmol) of ethyl 5-fluoro-1H-indole-2-carboxylate is added dropwise to a suspension of 0.38 g (9.45 mmol) of 60% sodium hydride in 10 ml of dimethylformamide, stirred at 0° C. under argon. The mixture is stirred for 30 minutes at 0° C. and then for 30 minutes at 20° C. The reaction mixture is cooled and 1.24 g (4.8 mmol) of 3-bromomethylpyridine hydrobromide are added portionwise. The mixture is stirred for 30 minutes at 0° C. and then for 30 minutes at 20° C. The reaction mixture is cooled again to 0° C. and a further 0.38 g (9.45 mmol) of 60% sodium hydride in 10 ml of dimethylformamide is added. After 30 minutes at 0° C., 1.24 g (4.8 mmol) of 3-bromomethylpyridine hydrobromide are added portionwise. The reaction mixture is stirred for 58 hours at 20° C. The mixture is then poured into a solution of 100 ml of ice-water and 100 ml of ethyl ether. The organic phase is separated out and the aqueous phase is re-extracted with 100 ml of ethyl ether. The organic phases are combined, washed with 50 ml of water and then dried over sodium sulfate, filtered and then concentrated under reduced pressure. The residue is purified by preparative chromatography (eluent: dichloromethane/acetone). 0.5 g of expected product is obtained in the form of a solid, which is used without further purification in the subsequent synthesis.

출처