반응 #47994

반응 방정식

Hydroxylamine hydrochloride

sodium acetate

5-n-butylindan-1-one

→

title compound

5-n-Butylindan-1-one oxime

용매

water

ethanol

water

반응 조건

후처리

1. 1
   온도The reaction is heated
2. 2
   온도to reflux for 20 minutes
3. 3
   추출the mixture is extracted with CH2Cl2
4. 4
   세척The combined organic extracts are washed with brine
5. 5
   건조dried (MgSO4)
6. 6
   기타evaporated

실험 절차

Hydroxylamine hydrochloride (0.89 g, 12.8 mmol) and sodium acetate (12.8 mmol) are added to a solution of 5-n-butylindan-1-one (1.0 g, 5.31 mmol) in ethanol (30 ml) and water (3 ml). The reaction is heated to reflux for 20 minutes, then water is added and the mixture is extracted with CH2Cl2. The combined organic extracts are washed with brine, dried (MgSO4) and evaporated to afford the title compound. NMR δH 0.86 (t J 7.3 3H), 1.28 (sextet J 7.3 2H), 1.52 (quintet J 7.3 2H), 2.55 (t J 8.0 2H), 2.85-3.0 (m 4H), 7.0 (d J 8.3 1H), 7.05 (s 1H), 7.45 (d J 8.3 2H)

출처