반응 #479609
ord-32fc6db824284f9f91ed2dd5ed977606
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The dark red reaction
- 2여과filtered
- 3농축concentrated to dryness
- 4기타The residue was purified by Biotage
- 5세척eluting with 3:1 to 2:1 DCM/EtOAc mixture
실험 절차
Into a 0° C. solution of N-(3-methoxycarbonylphenyl) pyrid-3-ylmethylamine (204 g, 0.842 mole, 1 eq) in dichloroethane (3610 mL) and pyridine (1775 mL) was added ethanesulfonyl chloride (114 mL, 1.2 mole, 1.43 eq). The reaction was allowed to warm to room temperature overnight. The dark red reaction was stirred with potassium carbonate (204 g) for 30 minutes and then filtered and concentrated to dryness. The residue was purified by Biotage, eluting with 3:1 to 2:1 DCM/EtOAc mixture to give the title compound as a white solid (137.0 g, 49% yield).