반응 #47945
ord-6ed28fddb3784930a872ce9efc7b88b1
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출the mixture was extracted with ethyl acetate
- 2세척The organic phase was washed with brine
- 3건조dried over anhydrous Na2SO4
- 4여과filtered
- 5농축concentrated under reduced pressure
- 6기타The crude product was purified by a silica SPE cartridge (10 g)
- 7세척eluting with dichloromethane/methanol from 100/0 to 99/1
실험 절차
To a solution of 2-(methylthio)-4-[(phenylmethyl)oxy]pyrimidine (P9, 245 mg) in THF/MeOH 1/1 (15.6 mL) was added a solution of Oxone® (2.6 g) in water (14 mL). After 40 min a saturated NaHCO3 solution was added and the mixture was extracted with ethyl acetate. The organic phase was washed with brine, dried over anhydrous Na2SO4 filtered and concentrated under reduced pressure. The crude product was purified by a silica SPE cartridge (10 g) eluting with dichloromethane/methanol from 100/0 to 99/1 to give the title compound as a white solid (230 mg).