반응 #47943

반응 방정식

2-(4-penten-1-yl)-4-(trifluoromethyl)pyrimidine

Water

→

title compound

4-[4-(trifluoromethyl)-2-pyrimidinyl]butanal

용매

THF H2O

반응 조건

후처리

1. 1
   추출the mixture extracted with DCM
2. 2
   세척The organic phase was washed with brine
3. 3
   건조dried over Na2SO4
4. 4
   여과filtered
5. 5
   기타evaporated in vacuo

실험 절차

To a solution of 2-(4-penten-1-yl)-4-(trifluoromethyl)pyrimidine (P7, 143 mg) in THF/H2O 5/1 (6.5 mL) were added OsO4 (4% in water, 0.2 mL) and NaIO4 (424 mg). The solution was stirred at r.t. for 30 min. Water was then added and the mixture extracted with DCM. The organic phase was washed with brine, dried over Na2SO4, filtered and evaporated in vacuo to give 91 mg of the title compound as an oil, which was used in the subsequent step without further purification.

출처