반응 #47917

반응 방정식

N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

m-tolylboronic acid

triethylamine

→

desired compound

수율 5.0%

N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-6-m-tolylpyrido[4,3-d]pyrimidin-4-amine

수율 5.0%

용매

THF

반응 조건

후처리

1. 1
   기타the solvent was removed under a vacuum
2. 2
   기타The residue was purified

실험 절차

N-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (100 mg, 0.34 mmol) was dissolved in anhydrous THF (2 mL). To the mixture was added m-tolylboronic acid (92 mg, 0.68 mmol), Cu(OAc)2 (124 mg, 0.68 mmol) and triethylamine (0.68 g, 0.095 mL). The mixture was agitated for 6 h and the solvent was removed under a vacuum. The residue was purified using a gradient of ethyl acetate:hexane (0-100%) to give the desired compound as reddish powder (6.2 mg, 5%).

출처